• Vaishnavi S. Pade
• Sneha S. Marlapalle
• Vaishnavi V. Nimje

Ketotifen fumarate is the fast disintegrating tablet. KF is a second -generation H1 Antihistamine and mast cell stabilizer. Ketotifen has antiallergic activity. Sublingual drug delivery can be alternative and better route as compared to oral drug delivery as sublingually administered dosage forms bypass hepatic metabolism. It show rapid onset of action therefore used in the treatment of acute disorder. Sublingual tablet disintegrated rapidly and small amount of saliva is sufficient for achieving disintegration of dosage form coupled with better dissolution and increase bioavailability. The Sublingual tablet of ketotifen fumarate was prepared by wet granulation method using active ingredient is ketotifen and excipients are microcrystalline cellulose, sodium starch glycolate, lactose monohydrate, anhydrous colloidal silicon dioxide, magnesium stearate, sucrose, sodium benzoate and titanium dioxide. Pre-formulation study of sublingual tablet such as melting point, solubility, bulk density, tapped density, angle of repose, carr’s index and Haunser ratio. The tablet are evaluated for post-compression parameters like general appearance, uniformity of tablet weight, hardness and thickness, wetting time, water absorption ratio, friability, disintegration and dissolution.

mouth dissolving, Ketotifen fumarate, fast disintegration, wetting time, increase bioavailability, allergic condition.

"FORMULATION AND EVALUATION OF KETOTIFEN FUMARATE SUBLINGUAL TABLET", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 3, page no.f418-f427, March-2025, Available :http://www.jetir.org/papers/JETIR2503578.pdf

"FORMULATION AND EVALUATION OF KETOTIFEN FUMARATE SUBLINGUAL TABLET", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 3, page no. ppf418-f427, March-2025, Available at : http://www.jetir.org/papers/JETIR2503578.pdf