• Sameer Sapkale
• Sana Tahreem Moiez Shaikh
• Rahul Salampure
• Prerna Sadawarte
• Dr. S.S. Angadi

The seeds of Syzygium cumini, also referred to as jamun or black plum, contain a complex phytochemical profile that includes alkaloids, tannins, phenolic compounds, and flavonoids, all of which have shown promise as medicines. The anticancer effects of jamun seed extracts on human laryngeal carcinoma (Hep-2) cells are examined in this work. The findings showed that the seed extracts successfully and dose-dependently suppressed the growth of Hep-2 cancer cells. According to mechanistic study, the anticancer effect is mediated by stimulating apoptosis, interfering with the course of the cell cycle, and producing more reactive oxygen species (ROS), which causes oxidative stress in cancer cells. The extracts also shown anti-angiogenic qualities, which further slowed the growth of tumours. These results demonstrate the potential of extracts from jamun seeds as a natural, bioactive agent for supplementary cancer treatment, which calls for more research into their active ingredients and possible uses in medicine.

Anti carcinoma, Eugenia jambolana, Human laryngeal epithelioma type 2 (Hep 2) cells

"Therapeutic Insights into Jamun (Syzygium cumini) Seed Extracts: Inhibition of Hep-2 Cancer Cell Growth and Beyond", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 3, page no.f433-f451, March-2025, Available :http://www.jetir.org/papers/JETIR2503580.pdf

"Therapeutic Insights into Jamun (Syzygium cumini) Seed Extracts: Inhibition of Hep-2 Cancer Cell Growth and Beyond", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 3, page no. ppf433-f451, March-2025, Available at : http://www.jetir.org/papers/JETIR2503580.pdf