• Rajeev Ranjan
• Sanjana Kushwaha
• Rahul Patel
• Manish Kumar Singh

The increasing prevalence of antibiotic-resistant Staphylococcus aureus, particularly Methicillin-resistant S. aureus (MRSA), poses a serious public health challenge worldwide. This study investigates the potential of bacteriophages as an alternative or complementary treatment to conventional antibiotics. Bacteriophages are viruses that specifically infect and kill bacteria without harming human cells, making them promising agents in the fight against resistant bacterial strains. The paper explores the biology of bacteriophages, including their specificity, replication mechanisms, and lifecycle, with a focus on their application against S. aureus. Experimental evidence from laboratory and clinical studies is examined to demonstrate their effectiveness in reducing bacterial load and disrupting biofilms associated with chronic infections. The study also discusses the advantages of phage therapy, such as minimal side effects, adaptability to bacterial mutations, and targeted action that spares beneficial microbiota. However, it also addresses potential limitations, including the development of phage-resistant bacteria, regulatory concerns, and immune system interactions. Despite these challenges, bacteriophage therapy shows great potential as a novel antimicrobial strategy. The study concludes by emphasizing the need for more research, standardized protocols, and clinical trials to fully integrate phage therapy into mainstream medical practice as a sustainable solution to antibiotic resistance.

Bacteriophage, Antibiotic, Drug resistance, Pathogen, Bacteria

"BACTERIOPHAGE AGAINST STAPHYLOCOCCUS AUREUS BACTERIA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 4, page no.k39-k46, April-2025, Available :http://www.jetir.org/papers/JETIR2504A06.pdf

"BACTERIOPHAGE AGAINST STAPHYLOCOCCUS AUREUS BACTERIA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 4, page no. ppk39-k46, April-2025, Available at : http://www.jetir.org/papers/JETIR2504A06.pdf