• Yogita Yadav
• Madhukar Gangadhar kasar
• Rajendra Singh

The synthesis of novel heterocyclic compounds is achieved through a multi-step process involving azo dye (COMPOUND 1), ester (COMPOUND 2), and hydrazide (COMPOUND3). Initially, azo dye (COMPOUND 1) is synthesized through the reaction between resorcinol and p-aminobenzoic acid. Subsequently, ester (COMPOUND 2) is formed by reacting azo dye (COMPOUND 2) with concentrated sulfuric acid. Hydrazide (COMPOUND 3) is then synthesized by reacting ester (S2) with 80% hydrazine hydrate. Further reactions of hydrazide COMPOUND 3 with various anhydrides (maleic anhydride, phthalic anhydride, 3-nitrophthalic anhydride, and succinic anhydride) result in cyclization facilitated by acetic acid, yielding six-membered heterocyclic compounds. Additionally, compound COMPOUND 3 undergoes cyclization with acetyl acetone, ethyl acetoacetate, methyl acetoacetate, and diethyl malonate to produce five-membered heterocyclic compounds. The biological activity of these synthesized compounds is also investigated. Characterization of the prepared compounds is performed using techniques such as Fourier-Transform Infrared Spectroscopy (FT-IR), Proton Nuclear Magnetic Resonance (1HNMR), Carbon-13 Nuclear Magnetic Resonance (13C-NMR), and Elemental Analysis (CHNS).

resorcinol; azo dyes; pyridazine; phthalazine; pyrazole; biological activity

" Study of Medicinal and Biological Activity of few Heterocyclic Compounds with moieties of Hydrazide,Azo and Ester, moiety", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 5, page no.a350-a357, May-2025, Available :http://www.jetir.org/papers/JETIR2505032.pdf

" Study of Medicinal and Biological Activity of few Heterocyclic Compounds with moieties of Hydrazide,Azo and Ester, moiety", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 5, page no. ppa350-a357, May-2025, Available at : http://www.jetir.org/papers/JETIR2505032.pdf