• R.Soundarya

The term drug interaction is defined as an alteration in the duration or magnitude or both of the pharmacological effect of one drug produced by another drug. When more than one drug is administered simultaneously the combined effect may be antagonistic or synergistic. In antagonism the effect of one drug is reduced or abolished by the other where in synergism the effects may be additive or supra-additive (potentiation). Apart from these phenomena numerous drug interactions are harmful and may produce severe toxic reactions. The incidence of such reactions as increased mainly due to three factors (i) drug explosion; (ii) availability of potent drugs and (iii) irrational polypharmacy, i.e., indiscriminate prescriptions of a number of preparations by the clinician (iatrogenic or doctor -induced diseases).

drug explosion, availability of potent drugs, Drug interactions.

"A STUDY ON DRUG-DRUG INTERACTION BETWEEN CANDESARTAN AND GLIMEPIRIDE IN RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 5, page no.a855-a867, May-2025, Available :http://www.jetir.org/papers/JETIR2505093.pdf

"A STUDY ON DRUG-DRUG INTERACTION BETWEEN CANDESARTAN AND GLIMEPIRIDE IN RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 5, page no. ppa855-a867, May-2025, Available at : http://www.jetir.org/papers/JETIR2505093.pdf