• Jargal Shahid
• Kajal Sahu
• Panchal Vaishvi

Herbal formulations for the treatment of oral ulcers represent a promising avenue in the development of alternative therapeutics due to their biocompatibility, minimal side effects, and synergistic action of multiple phytoconstituents. The current study focuses on the design and evaluation of a polyherbal mouth ulcer cream, integrating traditional Ayurvedic ingredients such as Psidium guajava (guava leaves), Piper betle (betel leaves), Ocimum sanctum (basil), Glycyrrhiza glabra (liquorice), Syzygium cumini (jamun seed), along with clove oil, neem oil, and pomegranate peel extract. The base of the formulation comprises a medicated Shata Dhauta Ghrita, prepared using therapeutic herbal decoctions in place of water. Extraction processes were optimized using microwave-assisted extraction and conventional decoction methods to retain maximum bioactivity. The final cream was evaluated through a series of physicochemical and microbiological tests including pH, spreadability, stability, antimicrobial activity, and skin irritation studies. Results indicate the formulation's potential as a safe, stable, and efficacious alternative for the management of oral ulcers.

Piper betle, Psidium guajava, Ocimum sanctum, Glycyrrhiza glabra, Syzygium cumini, clove oil, Anti-ulcer cream

"FORMULATION AND EVALUATION OF SHATA-DHAUTA GHRITA ANTI-ULCER CREAM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 5, page no.f373-f381, May-2025, Available :http://www.jetir.org/papers/JETIR2505640.pdf

"FORMULATION AND EVALUATION OF SHATA-DHAUTA GHRITA ANTI-ULCER CREAM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 5, page no. ppf373-f381, May-2025, Available at : http://www.jetir.org/papers/JETIR2505640.pdf