• Deena Antony. C
• Lisandra N R

In vitro cytotoxicity studies of a novel Schiff base ligand derived from the condensation of 4-hydroxy benzoyl hydrazide and 2-acetyl benzofuran (HBZABF) and its Cu (II), Ni (II) complexes are reported. The IR and UV-visible spectral data suggest the formation of the Schiff base ligand and its metal complexes. The percentages of carbon, hydrogen and nitrogen present in the Schiff base ligand and complexes are confirmed by Elemental analysis. The analytical results suggest that the Schiff base behaves as tridentate ONO donor ligand and coordinates with Cu (II) and Ni (II) ions in octahedral geometry. The ligand and its complexes are screened for their cytotoxicity. Cytotoxicity studies reveal that the Schiff base complex of copper exhibits considerable activity than the free Schiff base ligand. Copper complex of HBZABF showed 100 % cytotoxicity at a concentration of 200 µg/ml. Copper complex exhibited high cytotoxicity even in lower concentrations and it can be used as a promising anticancer drug after further investigations.

4-Hydroxy benzoyl hydrazide, 2-Acetyl benzofuran, Schiff base, Cytotoxicity

"In vitro Cytotoxicity studies of a novel Schiff base ligand derived from 4-hydroxy benzoyl hydrazide and 2-acetyl benzofuran and its Cu(II), Ni(II) metal complexes.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 5, page no.g128-g132, May-2025, Available :http://www.jetir.org/papers/JETIR2505713.pdf

"In vitro Cytotoxicity studies of a novel Schiff base ligand derived from 4-hydroxy benzoyl hydrazide and 2-acetyl benzofuran and its Cu(II), Ni(II) metal complexes.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 5, page no. ppg128-g132, May-2025, Available at : http://www.jetir.org/papers/JETIR2505713.pdf