• Ayush Raj
• Diksha Kumari
• Harsh Raj
• MD Talib

There are a million patients with Alzheimer's Disease (AD) according to international data in September 2021. AD is a progressive neurodegenerative disorder characterized by cognitive decline, neuronal loss, and the accumulation of amyloid-beta (Aβ) plaques and neurofibrillary tangles. Current therapeutic strategies primarily offer symptomatic relief, underscoring the urgent need for novel, disease-modifying treatments. Flavonoids, a diverse class of polyphenolic compounds found in plants, have shown promising neuroprotective properties due to their antioxidant, anti-inflammatory, and anti-amyloidogenic effects. This review examines the therapeutic potential of flavonoids in AD, focusing on molecular docking studies that elucidate their interactions with key AD targets, such as Aβ peptides, tau proteins, acetylcholinesterase (AChE), and other relevant enzymes. Computational docking analyses highlight the binding affinities and inhibitory mechanisms of various flavonoids, demonstrating their potential to disrupt Aβ aggregation, inhibit AChE activity, and mitigate oxidative stress. These findings provide compelling evidence for further preclinical and clinical investigations, suggesting flavonoids as promising candidates for AD therapy. Future research should aim to validate these in silico results through in vivo studies and explore the bioavailability and pharmacokinetics of flavonoid-based interventions. This review focuses on flavonoids and their role in AD, in terms of therapeutic potentiality for human health, antioxidant potential, and specific AD molecular targets.

Molecular Docking, Alzheimer’s disease, Flavonoids, Acetylcholinesterase, Acetylcholine

"Review of the Therapeutic Potential of Flavonoids in Alzheimer's Disease: Insight from Molecular Docking Validation.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 5, page no.h1-h7, May-2025, Available :http://www.jetir.org/papers/JETIR2505801.pdf

"Review of the Therapeutic Potential of Flavonoids in Alzheimer's Disease: Insight from Molecular Docking Validation.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 5, page no. pph1-h7, May-2025, Available at : http://www.jetir.org/papers/JETIR2505801.pdf