Abstract
Ointments are semisolid systems which usually behave as viscoelastic materials when shear
stress is applied. They generally contain medicaments and are intended to be applied externally
to the body or to the mucous membrane. Many medicaments meant for topical application to
intact or broken skin or to mucous membranes, have been presented in the form of semisolid
consistency variously designated as ointments, creams, salves, pastes etc used mainly as
protective or emollient for the skin. The first step towards this goal is the screening of plants
used in popular medicine. Along with other dosage forms, herbal drugs are also formulated in the
form of ointment 1 .Introduction Wound healing is a complex biological process involving
multiple stages, including hemostasis, inflammation, proliferation, and remodeling. In recent
years, herbal ointments have gained increasing attention due to their natural origin, low toxicity,
and cost-effectiveness. This study evaluates the efficacy of a herbal ointment formulated with
medicinal plant extracts traditionally used for wound treatment, including Centella asiatica, Aloe
vera, Curcuma longa, and Calendula officinalis. The phytochemical constituents of the
formulation, such as flavonoids, tannins, and terpenoids, contribute to its anti-inflammatory,
antimicrobial, and antioxidant properties. In vivo and in vitro assessments demonstrated that the
herbal ointment significantly accelerated wound contraction, enhanced re-epithelialization, and
reduced infection risk compared to standard treatments. These findings support the potential of
herbal-based ointments as effective alternatives or complementary therapies in wound
management. Further clinical studies are recommended to validate their therapeutic efficacy and
safety in broader populations.