• Hekad Jyoti Gajanan
• Tathe Prafulla Ramesh

Hyperlipidemic is a significant risk factor for cardiovascular diseases, including atherosclerosis, stroke, and coronary artery disease. Conventional lipid lowering drugs such as statins and fibrates are effective but may cause adverse effects. Promoting the search for natural alternatives to synthetic lipid-lowering drugs. Indigenous plants have been traditionally used in various cultures for their medicinal properties, including lipid lowering effects. This study reviews and evaluates the antilipidemic potential of selected indigenous plants, focusing on their bioactive compounds, mechanism of action and efficacy in preclinical and clinical studies. Key phytochemicals such as flavonoids, polyphenols, saponins, and alkaloids have shown a promising lipid lowering effect by modulating lipid metabolism, reducing cholesterol absorption, and enhancing antioxidant activity. Experimental and clinical studies indicates that plant extract from species like Terminalia arjuna, Allium sativum, Trigonella foenum-graecum, Camelia sinensis and Glycyrrhiza glabra (Licorice) significantly lower total cholesterol, LDL, and triglyceride levels while increasing HDL levels. This study examines the lipid-lowering activity of Glycyrrhiza glabra by analyzing its bioactive constituents and their mechanism of action. Key phytochemicals such glycyrrhizin, flavonoids, and saponins contribute to lipid metabolism regulation by cholesterol synthesis, enhancing bile acid secretion and exerting antioxidant and anti-inflammatory effects. Experimental and clinical studies indicates that the licorice extract significantly reduces low-density lipoprotein (LDL), and triglycerides while increasing high-density lipoprotein (HDL) levels. This finding suggests that glycyrrhiza glabra could serves as a natural alternative for managing hyperlipidemia. However, further clinical studies are required to establish standardized dosage and evaluate long-term safety and efficacy.

Cholesterol, Lipids, Hyperlipidemia, Glycyrrhiza glabra, Phytochemicals

"A COMPREHENSIVE REVIEW ON ANTI-LIPIDEMIC ACTIVITY OF GLYCYRRHIZA GLABRA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 5, page no.i725-i736, May-2025, Available :http://www.jetir.org/papers/JETIR2505983.pdf

"A COMPREHENSIVE REVIEW ON ANTI-LIPIDEMIC ACTIVITY OF GLYCYRRHIZA GLABRA", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 5, page no. ppi725-i736, May-2025, Available at : http://www.jetir.org/papers/JETIR2505983.pdf