• Sapkal Vaishnavi Haridas
• Tathe Prafulla Ramesh

Drug targeting is a modern drug delivery system. The goal of this review article is to introduce the basic conceptualization of drug targeting as it has advanced over previous decades. Deliver the drug to the targeted site without modifying or altering the other non-targeted site. The drug delivery system is to support the patient by designing an essential formulation. A drug delivery system is able to intensify the most important chemical features and biological properties of targeted drug delivery, sometimes called smart drug delivery. This method is a discrete dosage form that is applied to healthy skin in which there are no breaks, scrapes, cuts, or abnormal openings that allow pathogens to enter at a controlled rate to the systemic circulation. Genetically Targeted Drug Delivery System is an advanced technology for genetic disease management. The main purpose of a genetically targeted drug delivery system is to enhance therapeutic efficacy and minimize side effects by precisely delivering drugs to specific cells or tissues, particularly those affected by diseases like cancer, through genetic targeting mechanisms. This system aims to deliver drugs to the desired location (e.g., tumour cell) for genetically targeted drug delivery. Carriers like liposomes, nanoparticles (including polymers and solid lipid nanoparticle .and viral vectors are commonly used to transport genetic material (DNA or RNA) to specific cells or tissues and enhance the penetration of cell membranes or tissues more effectively. Also, these carriers can protect drugs or genetic material from degradation or premature release in the bloodstream. Active and passive targeting are two types of techniques used for targeted drug delivery. Targeted drug delivery improved pharmacokinetics, such as increased absorption and distribution, reduced side effects, avoidance of hepatic first-pass metabolism, lower doses compared to conventional drug delivery, reduced fluctuation in circulating drug levels, etc. A genetically targeted drug delivery system is a useful delivery system that uses techniques like gene therapy and nanotechnology, offers precise and targeted drug delivery, improves efficacy, and reduces side effects compared to traditional methods.

Gene, DNA, Amino Acid, targeted drug delivery, gene targeting, Nanoparticle, Viral vector, non -viral vector, Treatment.

"A Review on Genetically Targeting Drug Delivery System", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 5, page no.i750-i757, May-2025, Available :http://www.jetir.org/papers/JETIR2505986.pdf

"A Review on Genetically Targeting Drug Delivery System", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 5, page no. ppi750-i757, May-2025, Available at : http://www.jetir.org/papers/JETIR2505986.pdf