• Deep Ravindra Tope
• Namrata N. Dhote
• Dnyaneshwari S. Gaigole
• Nikita V. Mahalle
• Dr. Harigopal S. Sawarkar

This study focuses on the evaluation of adverse drug reactions (ADRs) associated with furosemide use in patients with chronic kidney failure (CKF). Furosemide, a high-ceiling loop diuretic, remains central in managing fluid overload and hypertension in CKF; however, its clinical benefits are frequently offset by a significant risk of ADRs, especially in individuals with compromised renal function. Through careful observation, the study identified common adverse effects such as electrolyte imbalances (hypokalemia, hyponatremia, hypomagnesemia), dehydration, volume depletion, hypotension, and polyuria. Severe outcomes including ototoxicity, acute kidney injury, and life-threatening arrhythmias were also reported, particularly in high-dose or rapid intravenous administration settings. Rare but critical adverse events like Stevens-Johnson Syndrome (SJS), pancytopenia, hepatic encephalopathy, interstitial nephritis, and acute pancreatitis were documented, underscoring the necessity of vigilant patient monitoring. Drug interactions with agents such as aminoglycosides, NSAIDs, ACE inhibitors, and digoxin further amplified the risk profile. The findings emphasize that personalized dosing strategies, regular electrolyte and renal function monitoring, and heightened pharmacovigilance are vital for minimizing adverse outcomes. In conclusion, while furosemide remains indispensable in the symptomatic management of CKF, its safe use demands a patient-specific, closely supervised approach. Enhanced awareness of its potential risks and proactive management of ADRs can significantly improve patient safety and therapeutic success in chronic kidney failure treatment.

CKF, Furosemide, ADR, Pharmacovigilance.

"Pharmacovigilance of Furosemide in Chronic Kidney Failure.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 5, page no.k256-k292, May-2025, Available :http://www.jetir.org/papers/JETIR2505B19.pdf

"Pharmacovigilance of Furosemide in Chronic Kidney Failure.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 5, page no. ppk256-k292, May-2025, Available at : http://www.jetir.org/papers/JETIR2505B19.pdf