• Dr.K.Saritha
• KUMMARI SINDHU
• THAMMAPPAGARI SRUTHI
• TELUGU JYOTHI
• KMD.JAHEED

The present study involves design and insilico evaluation (E)-N-(substituted benzylidene)nicotinohydrazide derivatives (substitutedbenzylidene)nicotinohydrazide derivatives.studies were done by using online software tools like Molinspiration, Swiss ADME, Swiss Target Prediction, and molecular docking to evaluate pharmacokinetic properties, druglikeness, bioactivity scores, and binding affinity to potential therapeutic targets. All the designed compounds satisfied Lipinski's rule of five, suggesting good oral bioavailability and favourable drug like lines behaviour. Molecular docking score indicated that the compounds exhibited strong binding affinity with targets such as the cox2 and endothelin receptor . Among the series, compounds 2 and 3 showed potential activity .These findings indicate the promising potential of pyridine derivatives in future drug development, especially in anti-inflammatory, anti-oxidant, anti-microbial and infectious disease treatment.

Pyridine, Molinspiration, Swiss ADME, Swiss Target Prediction, and Swiss docking.

"DESIGN AND INSILICO EVALUATION OF (E)-N-(SUBSTITUTEDBENZYLIDENE) NICOTINOHYDRAZIDE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 6, page no.a417-a457, June-2025, Available :http://www.jetir.org/papers/JETIR2506044.pdf

"DESIGN AND INSILICO EVALUATION OF (E)-N-(SUBSTITUTEDBENZYLIDENE) NICOTINOHYDRAZIDE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 6, page no. ppa417-a457, June-2025, Available at : http://www.jetir.org/papers/JETIR2506044.pdf