• Aafrin Sheikh
• Dr. Dinesh Biyani
• Dr. Milind Umekar

The main aim of the present study is to increase solubility of poorly soluble drug nitrofurantoin. Orally administered drug are moderately soluble in the stomach environment and have good bioavailability if they can be entirely absorbed when taken orally. More than 40% of the NCEs (new chemical entities) introduced in the pharmaceutical industry recently are practically water insoluble. These medications have weak water solubility combined with slow drug absorption causes insufficient and unpredictable bioavailability as well as damage to the gastrointestinal mucosa. Therefore, one of the most difficult components of the drug development process, particularly for oral drug delivery system, is to improve drug solubility in order to increase its oral bio-availability. One of the key characteristics to achieve desired pharmacological response is solubility. The solubility of the drug moiety determines its therapeutic effectiveness. Therapeutic effectiveness of a drug depends upon the bioavailability1. Orally administered drug are moderately soluble in the stomach environment and have good bioavailability if they can be entirely absorbed when taken orally. More than 40% of the NCEs (new chemical entities) introduced in the pharmaceutical industry recently are practically water insoluble.

Solubility Enhancement, Hydrotropy, Nitrofurantoin, Solubility

"HYDROTROPIC SOLUBILITY ENHANCEMENT OF NITROFURANTOIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 6, page no.h701-h717, June-2025, Available :http://www.jetir.org/papers/JETIR2506789.pdf

"HYDROTROPIC SOLUBILITY ENHANCEMENT OF NITROFURANTOIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 6, page no. pph701-h717, June-2025, Available at : http://www.jetir.org/papers/JETIR2506789.pdf