• Dr. Manchineni Prasada Rao
• Dr. V. Rajini
• Dr. Y. Narasimha Rao
• Bandarupalli Sri Sirisha

Polypharmacy, commonly defined as the concurrent use of five or more medications, is increasingly prevalent among elderly and chronically ill patients. polypharmacy is sometimes required to treat complicated health disorders, it considerably increases the risk of drug-drug interactions (DDIs), which can lead to reduced therapeutic efficacy, toxicity, or serious adverse drug reactions. This review investigates the pharmacokinetic and pharmacodynamic mechanisms underpinning DDIs and identifies the primary risk variables that contribute to clinically significant interactions. Real-world instances, such as warfarin-azithromycin or ACE inhibitors with potassium-sparing diuretics, highlight the potential severity of these events. Pharmacist interventions, including dose adjustments, deprescribing strategies, and the use of interaction-checker tools, contribute significantly to enhancing patient safety. Additionally, the implementation of electronic prescribing systems, interdisciplinary collaboration, and continuous monitoring are essential in minimizing DDI-related harm. Recognizing and addressing DDIs within polypharmacy is a key responsibility in modern healthcare, with clinical pharmacists serving as frontline guardians of safe medication use.

Polypharmacy, Drug Interactions, Pharmacist Interventions, Adverse Drug Reactions, Risk Management, Patient Safety

"Drug–Drug Interactions in Polypharmacy: A Clinical Review of Mechanisms, Risk Management, and Clinical Pharmacist Interventions", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 6, page no.i335-i339, June-2025, Available :http://www.jetir.org/papers/JETIR2506844.pdf

"Drug–Drug Interactions in Polypharmacy: A Clinical Review of Mechanisms, Risk Management, and Clinical Pharmacist Interventions", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 6, page no. ppi335-i339, June-2025, Available at : http://www.jetir.org/papers/JETIR2506844.pdf