• Roopa Karki
• DigeshChanda
• Hemalatha YR
• Venkatesh DP
• Prakash T

Verapamil hydrochloride is a calcium channel blocker, widely used in management of hypertension. It has very short half-life of 4h and oral bioavailability of 35.1%. The present investigation was concerned with the development of floating microspheres of verapamil hydrochloride to target the drug to its absorption site by increasing the residence time of drug in stomach and to control drug release in therapeutic range for longer period of time. Floating microspheres of verapamil hydrochloride were prepared by non-aqueous solvent evaporation technique using ethyl cellulose and hydroxypropyl methyl cellulose (HPMC) in different ratios. The prepared microsheres were evaluated for particle size, surface topography, yield, percentage drug entrapment efficiency, percentage buoyancy, in-vitro drug release and drug release kinetics were evaluated using the linear regression method. Stability study was carried out for 3months.Results showed that particle size (45.01± 2.3 μm to 113.02±3.2 μm), yield (79.51±3.715 to 93.48±0.946), drug content (82.25±0.367 to 91.02± 1.169) and drug release of microspheres (12hour), stability was showed not much change in the optimized formulation (F4) and the best results were obtained at the ratio of drug: EC: HPMC (333.3:166.6). In most cases good in vitro floating behavior was observed and broad variety of drug release pattern could be achieved by variation of polymer ratio, which was optimized to match target release profile. The developed floating microspheres of verapamil hydrochloride were used for effective management of hypertension.

Verapamil Hydrochloride floating microspheres ethyl cellulose hydroxy methylcellulose

"Formulation, characterization and invitro evaluation of floating microspheres of Verapamil Hydrochloride", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 6, page no.j238-j251, June-2025, Available :http://www.jetir.org/papers/JETIR2506929.pdf

"Formulation, characterization and invitro evaluation of floating microspheres of Verapamil Hydrochloride", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 6, page no. ppj238-j251, June-2025, Available at : http://www.jetir.org/papers/JETIR2506929.pdf