• Mahanam Brata Paul
• Sayan Ghosh
• Sudipta Modak

Peptic ulcer disease (PUD) constitutes a multifactorial and intricate pathology resulting from a dysregulation between protective and aggressive determinants (both endogenous and exogenous). Notwithstanding recent advancements, it continues to account for considerable morbidity and precipitating clinical challenges. In India The point prevalence of peptic ulcers was recorded at 4.72%, while the lifetime prevalence was documented at 11.22%. Gastroretentive Drug Delivery Systems (GRDDS) represent sophisticated pharmaceutical formulations engineered to prolong the duration a drug remains within the gastric environment, thereby augmenting its therapeutic effectiveness and bioavailability. Such systems are especially advantageous for compounds that exhibit suboptimal absorption in the distal gastrointestinal region or necessitate extended gastric retention to achieve maximal therapeutic impact.The bioavailability of gastroretentive floating microspheres that are sufficient buoyancy to float over gastric contents and remain in stomach due to low density systems that’s why drug release is enhanced in the plasma drug concentration.Floating microsphere are solvent- evaporation method in that solvent – polymer ratio combination those characterizations of particle size analysis ,drug entrapment efficiency,scanning electron microscopy ,in-vitro release release,In- vitro buoyancy ,stability studies which shows better absorption ,increase the bioavailability and sustained release in the stomach.special categories of proton pump inhibitors ,antacids,antidiabetic,anti-fungal,anti-ulcer formulated into floating drug delivery system. These systems additionally offer significant prospects in the formulation of novel controlled and delayed release oral preparations, thereby pushing the boundaries of advanced pharmaceutical innovation.In that review pathophysiology of gastric ulcers , gastro retentive floating system approach ,advantages of preparation methods of floating microsphere,application are discussed.

PEPTIC ULCERS.GASTRO RETENTIVE DRUG DELIVERY SYSTEM,FLOATING MICROSPHERE,IN -VITRO BUOYANCY.

"RECENT ADVANCES IN THE DEVELOPMENT OF FLOATING MICROSPHERES FOR THE TREATMENT OF GASTRIC ULCERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 7, page no.a320-a334, July-2025, Available :http://www.jetir.org/papers/JETIR2507033.pdf

"RECENT ADVANCES IN THE DEVELOPMENT OF FLOATING MICROSPHERES FOR THE TREATMENT OF GASTRIC ULCERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 7, page no. ppa320-a334, July-2025, Available at : http://www.jetir.org/papers/JETIR2507033.pdf