• Mr. Nilesh A. Nalkol
• Mr. Annasaheb N. Golekar
• Dr. Sunil D. Kolhe

Menthosomal gels are a new efficient system for the drug delivery system which use the ability of the menthol to enlarge the skin permeability, and lipid vesicle structures. These formulations respond to problems typical of conventional drugs and dosage forms, including solubility, biopharmaceutical and pharmacokinetic problems, as well as side effects due to systemic delivery. As menthol dissolves the lipid layer of the SC, the menthosomal gels improve skin penetration and drug accumulation. Their ability to encapsulate both polar and non-polar drugs increases the possibilities for their use in dermatological, transdermal, systemic, and cosmetic spheres. This review aims to discuss the advancement, assessment, and uses of the menthosomal gels. It covers formulation approaches in terms of choice of lipids, cholesterol, menthol, gel bases and techniques of manufacture as thin film hydration and sonication. Detailed description of physicochemical characterization techniques, in vitro drug release profiles, and in vivo efficacy testing are described to demonstrate their efficiency and safety. It can be used for the topical treatment of diseases like psoriasis and acne as well as to deliver systemically administered drugs like hormones and NSAID’s. Moreover, menthosomal gels could be used in activities such as wound healing, along with anti-aging properties and a method to deliver vaccines through the skin. While there are benefits of adopting concepts on SC in ASION, there are limitations or issues which can be attributed to scalability, stability, and the issue of getting appropriate approval from relevant authorities. The positive implications in present day practice in modern medicine are expected to be amplified by future evolution of such technologies such as integration of AI technology, personalized medicine, sustainable practices and many others. As current shortcomings show, menthosomal gels are all set to recast drug delivery as an innovative, patient-centered approach.

Drug delivery; Menthol; Menthosomal gels; Permeation enhancement; Transdermal systems; Vesicular systems

"Development, Evaluation, and Applications of Menthosomal Gels in Current Medicine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 7, page no.b208-b220, July-2025, Available :http://www.jetir.org/papers/JETIR2507124.pdf

"Development, Evaluation, and Applications of Menthosomal Gels in Current Medicine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 7, page no. ppb208-b220, July-2025, Available at : http://www.jetir.org/papers/JETIR2507124.pdf