• Shivam Bhargava
• Chitra Gupta

Mouth-dissolving nanofibers represent a significant advancement in oral drug delivery, offering rapid disintegration and dissolution in the oral cavity without the need for water. This review article provides a comprehensive overview of the recent developments in the fabrication of mouth-dissolving nanofibers, with a particular focus on electrospinning as the primary manufacturing technique. It delves into the diverse range of polymers employed, the various drug loading strategies, and the critical parameters influencing nanofiber properties. Furthermore, the article extensively discusses the essential characterization techniques utilized to assess the physical, chemical, mechanical, and dissolution performance of these innovative dosage forms. Finally, it highlights the promising applications of mouth-dissolving nanofibers, addressing their advantages for specific patient populations and their potential to enhance drug bioavailability and patient compliance.

Mouth-Dissolving, Nanofiber, Drug Delivery System, Oro-Dispersible ,FTIR, SEM

"Development and Characterization of Mouth dissolving nanofibers of dextromethorphan", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 7, page no.c526-c538, July-2025, Available :http://www.jetir.org/papers/JETIR2507259.pdf

"Development and Characterization of Mouth dissolving nanofibers of dextromethorphan", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 7, page no. ppc526-c538, July-2025, Available at : http://www.jetir.org/papers/JETIR2507259.pdf