• Rayan Das

Reproductive aging, characterized by the progressive decline in ovarian function and hormonal regulation, has been extensively investigated using rodent models, particularly rats and mice. These models have provided crucial insights into the biological, hormonal, neuroendocrine, and molecular mechanisms underlying reproductive senescence. Follicular atresia and reduction in ovarian reserve, coupled with disrupted levels of gonadotropins (FSH, LH) and sex steroids (estrogen, progesterone), have been consistently observed in aging rodents, closely resembling human menopausal transitions. Alterations in the hypothalamic-pituitary-gonadal (HPG) axis, including dysregulated GnRH secretion and age-related changes in kisspeptin and neurokinin B signaling, have further clarified the central neuroendocrine control of fertility loss. Genetic studies using knockout and transgenic mice have revealed key molecular players in reproductive aging, including hormone receptors and senescence markers. Environmental factors such as diet, stress, and endocrine disruptors have also been explored using rodent models to assess intervention strategies. Despite species-specific limitations, rodent models remain indispensable for bridging basic science with translational applications. The integration of omics technologies, advanced imaging, and artificial intelligence promises to refine these models further, enhancing their relevance for human reproductive health research and potential therapeutic development.

Reproductive aging, Rodent models, Ovarian reserve, HPG axis, Hormonal regulation, Transgenic mice

"UNRAVELLING REPRODUCTIVE SENESCENCE: INSIGHTS FROM RAT AND MOUSE MODELS IN AGING RESEARCH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 7, page no.d516-d527, July-2025, Available :http://www.jetir.org/papers/JETIR2507360.pdf

"UNRAVELLING REPRODUCTIVE SENESCENCE: INSIGHTS FROM RAT AND MOUSE MODELS IN AGING RESEARCH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 7, page no. ppd516-d527, July-2025, Available at : http://www.jetir.org/papers/JETIR2507360.pdf