• Ms.Mayuri More
• Ms.Sakshi Bhosale

The two most often utilized local anesthetics for treating pain are lidocaine and prilocaine. For regional anesthetic, these drugs are frequently applied topically in the form of creams and patches. The dosages for both medications are 1:1 by weight. Because of their ease of use and capacity for achieving systematic medication absorption, transdermal drug delivery methods have become more and more common. Transdermal patches provide an alternative to conventional injections or oral drugs in the cases of lidocaine and prilocaine. But to maximize their clinical utility, we must comprehend the pharmacokinetics and cutaneous effects of these patches. Transdermal patches can be prepared using a variety of techniques; in this case, the solvent casting process is used to make local anesthetic patches for minor skin surgery or to reduce discomfort related to a range of disorders. By preventing the entry of sodium ions into nerve fibers, lidocaine and prilocaine block voltage-gated sodium channels, producing an anesthetic effect. They obstruct pain signals by preventing the production and transmission of action potentials. Effective drug distribution is made possible by the eutectic mixture of prilocaine and lidocaine, which increases the drugs' skin-permeable and soluble properties. The goal of the present inquiry is to create and assess the transdermal patches for the local anesthetic medications Lidocaine and Prilocaine, film-forming polymers like Hydroxypropyl methyl cellulose, plasticizers like Propylene Glycol and other essential additives.

Anesthesia, Lidocaine, prilocaine, solvent casting method, absorption, solubility, permeability.

"“TRANSDERMAL PATCHES CONTAINING LIDOCAINE AND PRILOCAINE FOR LOCAL ANESTHESIA”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 7, page no.d692-d706, July-2025, Available :http://www.jetir.org/papers/JETIR2507376.pdf

"“TRANSDERMAL PATCHES CONTAINING LIDOCAINE AND PRILOCAINE FOR LOCAL ANESTHESIA”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 7, page no. ppd692-d706, July-2025, Available at : http://www.jetir.org/papers/JETIR2507376.pdf