• Kuldeep Kaur
• Jatin sharma
• Neha sharma
• Dr. Lovkesh Bhatia

Alzheimer’s disease is a progressive neurodegenerative disorder that gradually impairs memory, reasoning, and daily functioning. It is the leading cause of dementia worldwide, primarily affecting older adults, and its prevalence continues to rise with the aging population. Despite decades of research, a definitive cure remains elusive. However, breakthroughs in understanding the disease's molecular and clinical features have led to early diagnostic tools and novel treatment strategies. This review offers a comprehensive overview of Alzheimer’s disease, starting with its history, rising global burden, and associated risk factors—both modifiable and non-modifiable. It explores the underlying pathophysiological mechanisms, including amyloid plaques, tau tangles, neuroinflammation, and oxidative stress, which disrupt brain function and contribute to cognitive decline. Clinical stages from preclinical to severe Alzheimer’s are discussed, highlighting how symptoms evolve over time. We also examine current diagnostic techniques and biomarkers, such as brain imaging and cerebrospinal fluid analysis, which allow earlier and more accurate detection. Therapeutic approaches are classified into symptomatic treatments, disease-modifying drugs, and nonpharmacological interventions aimed at improving quality of life. In addition, lifestyle-based preventive strategies—like physical activity, diet, and cognitive engagement—are gaining attention for reducing disease risk. Looking ahead, the future of Alzheimer’s care lies in personalized medicine, emerging immunotherapies, and AI-driven technologies for early prediction and remote monitoring. By organizing this knowledge in a clear and accessible format, the review aims to promote awareness, encourage early diagnosis, and support compassionate care for those affected.

Alzheimer’s disease; Dementia; Neurodegeneration; Amyloid-beta; Tau protein; Cognitive decline; Biomarkers; Disease-modifying therapies; Neuroinflammation; Lifestyle interventions

"Breaking the Silence of Alzheimer's: A Modern Synthesis of Mechanisms, Markers, and Management", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 7, page no.e269-e284, July-2025, Available :http://www.jetir.org/papers/JETIR2507441.pdf

"Breaking the Silence of Alzheimer's: A Modern Synthesis of Mechanisms, Markers, and Management", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 7, page no. ppe269-e284, July-2025, Available at : http://www.jetir.org/papers/JETIR2507441.pdf