• Divvala Monika1
• M..Gayatri Devi2
• Nagamani.B
• P. Uma Devi4

Gastroretentive drug delivery systems (GRDDS) represent a promising advancement in oral drug administration, particularly for drugs with narrow absorption windows, pH-sensitive stability, or local gastric action. These systems aim to enhance drug bioavailability by prolonging gastric residence time, thereby ensuring controlled and site-specific drug release. This review explores the anatomical and physiological considerations of the stomach relevant to GRDDS development, discusses the types of drugs suited for such systems, and outlines the key limitations and factors affecting gastric retention. Various GRDDS technologies are examined, including loading systems, high-density systems, mucoadhesive systems, expandable systems, super porous hydrogels, and magnetic systems, each with distinct mechanisms to achieve prolonged retention. The review also emphasizes material selection, formulation challenges, and evaluation methods for GRDDS. Overall, GRDDS hold significant potential in improving therapeutic outcomes, patient compliance, and targeted delivery, especially for drugs with limited bioavailability in the lower gastrointestinal tract.

Gastroretentive Drug Delivery Systems (GRDDS), Gastric Retention, Controlled Release , Floating Drug Delivery , Mucoadhesive Systems, Bioavailability ,Swelling Systems ,Magnetic Systems ,High-Density Dosage Forms ,Oral Drug Delivery ,Gastric Residence Time ,Site - Specific Delivery

"Strategies for Prolonged Gastric Retention: An Overview of GRDDS Technologies ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 7, page no.e602-e612, July-2025, Available :http://www.jetir.org/papers/JETIR2507485.pdf

"Strategies for Prolonged Gastric Retention: An Overview of GRDDS Technologies ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 7, page no. ppe602-e612, July-2025, Available at : http://www.jetir.org/papers/JETIR2507485.pdf