• Vaishnavi khandwe
• Puja Pande
• Dr. R.J.Mandade
• Dr. V.N.Deshmukh

The liver performs numerous essential physiological functions, including detoxification, metabolic regulation, and maintenance of biochemical equilibrium. Hepatic damage caused by exposure to toxic substances such as alcohol, pharmaceutical drugs, and environmental chemicals continues to present a major clinical concern. Commonly implicated medications in liver injury include rifampicin, isoniazid, methotrexate, azathioprine, amiodarone, and galactosamine. Conventional hepatoprotective agents such as silymarin, N-acetylcysteine (NAC), glycyrrhizinic acid, S-adenosylmethionine, cholestyramine, polyene phosphatidylcholine, glucocorticoids, immunosuppressant, and bicyclol are routinely used due to their antioxidant, anti-inflammatory, and cytoprotective effects. However, these agents often come with challenges such as high cost, adverse effects, and long-term safety concerns. As an alternative, several herbal medicines have gained attention for their hepatoprotective abilities. These plant-based remedies offer multitargeted benefits including stabilizing liver cell membranes, inhibiting lipid peroxidation, scavenging free radicals, and modulating detoxification enzymes. Extracts from medicinal plants such as Phyllanthus amarus, Andrographis paniculata, Boerhavia diffusa, Salvia miltiorrhiza, Astragalus membranaceus, Capparis spinosa, Cichorium intybus, and Solanum nigrum have shown significant hepatoprotective potential in experimental studies. These observations sort the rising interest in phytotherapeutics as safer and effective alternatives for treating liver-related disorders.

Hepatoprotective agents, Herbal medicines, Liver toxicity, Antioxidants, Liver disorders.

"“A scientific review comparing the effectiveness of standard medications and herbal extracts in hepatoprotection”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 7, page no.f40-f56, July-2025, Available :http://www.jetir.org/papers/JETIR2507505.pdf

"“A scientific review comparing the effectiveness of standard medications and herbal extracts in hepatoprotection”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 7, page no. ppf40-f56, July-2025, Available at : http://www.jetir.org/papers/JETIR2507505.pdf