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July-2025
eISSN: 2349-5162
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Journal of Emerging Technologies and Innovative Research ( An International Scholarly Open Access Journal, Peer-reviewed, Refereed, Crossref DOI Journal )
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UGC Approved Journal no 63975(19)
New UGC Peer-Reviewed Rules
ISSN: 2349-5162 | ESTD Year : 2014 Volume 13 | Issue 2 | February
New UGC Peer-Reviewed Rules
ISSN: 2349-5162 | ESTD Year : 2014 Volume 13 | Issue 2 | February
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UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975
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Published Paper ID:
JETIR2507764
Registration ID:
567484
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Title
Synthesis and Characterization of 2-methylindolizino[1,2-b]quinolin-9(11H)-one
Abstract
Camptothecin is a natural quinoline alkaloid, initially extracted from the bark of the Chinese tree Camptotheca acuminata, which acts as a powerful anti-cancer agent by inhibiting DNA topoisomerase I. Number of Camptothecin analogs synthesized by researchers to find potent anticancer drug. Camptothecin drug having Quinoline and 2-pyrodone moiety in their structure have biological activity and their derivatives are used in number of drugs. In present work a Tetracyclic (ABCD) ring core of camptothecin was synthesized by simple method using simple starting material like aniline derivatives and 2-pyridone in six steps. The intermediates were confirmed and characterized by FT-IR, LC-MS and 1HNMR.
Key Words
Camptothecin, Quinoline, 2-pyridone
Cite This Article
"Synthesis and Characterization of 2-methylindolizino[1,2-b]quinolin-9(11H)-one", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 7, page no.h478-h485, July-2025, Available :http://www.jetir.org/papers/JETIR2507764.pdf
ISSN
2349-5162 | Impact Factor 7.95 Calculate by Google Scholar
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Cite This Article
"Synthesis and Characterization of 2-methylindolizino[1,2-b]quinolin-9(11H)-one", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 7, page no. pph478-h485, July-2025, Available at : http://www.jetir.org/papers/JETIR2507764.pdf
Publication Details
Published Paper ID: JETIR2507764
Registration ID: 567484
Published In: Volume 12 | Issue 7 | Year July-2025
DOI (Digital Object Identifier): https://doi.org/10.56975/jetir.v12i7.567484
Page No: h478-h485
Country: Karwi, Chitrakoot (U.P.), Uttar Pradesh, India .
Area: Chemistry
ISSN Number: 2349-5162
Publisher: IJ Publication
Published Paper URL :: https://www.jetir.org/view?paper=JETIR2507764
Published Paper PDF: https://www.jetir.org/papers/JETIR2507764
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