• Shivangi Singh Kushwaha
• Surendra Jain
• Vinod Dhote
• Kanika Dhote

Peptic ulcer disease (PUD) is a significant gastrointestinal disorder caused by an imbalance between aggressive factors like gastric acid and pepsin, and defensive factors such as mucosal barrier and blood flow. The prevalence of PUD has decreased due to effective Helicobacter pylori eradication treatments, but the widespread use of non-steroidal anti-inflammatory drugs (NSAIDs) continues to cause gastrointestinal complications. This study investigates the anti-ulcerogenic potential of an ethanolic seed extract of Cullen corylifolium, a plant known for its traditional medicinal uses and rich phytochemical composition. The research involved preliminary, quantitative estimation of phenols and flavonoids, and an in vivo study using an indomethacin-induced ulcer model in Wistar rats. The results indicate that the extract possesses significant anti-ulcer properties, which may be attributed to its high content of phenols and flavonoids.

Peptic ulcer disease, Helicobacter pylori , non-steroidal anti-inflammatory drugs, phytochemical screening

"Evaluation of the Anti-ulcerogenic Activity of Cullen corylifolium Seed Extract", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 8, page no.e635-e643, August-2025, Available :http://www.jetir.org/papers/JETIR2508485.pdf

"Evaluation of the Anti-ulcerogenic Activity of Cullen corylifolium Seed Extract", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 8, page no. ppe635-e643, August-2025, Available at : http://www.jetir.org/papers/JETIR2508485.pdf