• Swati Bairagi
• Kanika Dhote
• Vinod Dhote

Epilepsy, a prevalent neurological disorder, is characterized by recurrent seizures and is often challenging to manage with conventional antiepileptic drugs (AEDs) due to their significant side effects and the emergence of drug resistance. This study was undertaken to scientifically validate the traditional use of Begonia malabarica as a natural remedy for epilepsy. We investigated the phytochemical profile and in vivo antiepileptic activity of the hydroalcoholic extract of the plant. The extract was found to be rich in bioactive compounds, including flavonoids and phenols. Its antiepileptic efficacy was evaluated using both pentylenetetrazole (PTZ)-induced and maximal electroshock seizure (MES) models in animal subjects. The results demonstrate that the Begonia malabarica extract significantly reduced the incidence, severity, and duration of seizures in both models, suggesting its potential as a novel, plant-based therapeutic agent for epilepsy.

Epilepsy, antiepileptic drugs, Begonia malabarica, phytochemical screening, pentylenetetrazole

"Antiepileptic Activity of Hydroalcoholic Extract of Begonia malabarica", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 8, page no.e661-e669, August-2025, Available :http://www.jetir.org/papers/JETIR2508489.pdf

"Antiepileptic Activity of Hydroalcoholic Extract of Begonia malabarica", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 8, page no. ppe661-e669, August-2025, Available at : http://www.jetir.org/papers/JETIR2508489.pdf