Abstract
Ksheenashukra, characterized by diminished quantity and quality of shukra dhatu, correlates with oligozoospermia in modern medicine, a major cause of male infertility. Ayurveda offers a comprehensive approach through Vajikarana tantra, focusing on shukrala dravyas—substances that nourish and promote shukra dhatu. This review explores classical references and modern research highlighting the role of shukrala dravyas like Ashwagandha, Shatavari, Kapikacchu, Gokshura, and others in managing ksheenashukra. These herbs, rich in phytoconstituents like withanolides, L-DOPA, and saponins, exhibit spermatogenic, antioxidant, and aphrodisiac properties. The mode of action is explained through Ayurvedic principles such as Rasa Panchaka (Rasa,Guna,Virya,Vipaka and Prabhava). Madhura rasa, guru-snigdha guna, and madhura vipaka are considered most effective in enhancing shukra. These drugs influence neuroendocrine pathways, nitric oxide signaling, and androgenic activity. Research supports their efficacy in improving sperm count, motility, hormone balance, and reducing oxidative stress. Thus, integrating classical wisdom with modern evidence validates the therapeutic potential of shukrala dravyas in treating male infertility. This review advocates a holistic, evidence-based Vajikarana approach to managing ksheenashukra (oligozoospermia).