• Harsh Dinkar
• Ms.Shivani suryawanshi
• Dr.Jagdish Chandra Rathi

This study aimed to assess the nephroprotective effects of two pomegranate extracts, pomegranate juice (PJ) and pomegranate peel methanol extract (PPME) in rats with chronic renal failure (CRF) induced by adenine (AD). Thirty six male rats were allocated into six groups: Control (CO), PJ, PPME, AD, AD+PJ and AD+PPME groups. The obtained results showed a significant increase in serum levels of creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA) in AD-fed rats. In addition, relative kidney weight, urine volume and urine NAG activity were significantly increased, while creatinine clearance was decreased. A significant disturbance was observed in antioxidant system of AD-fed rat group represented by elevations in thiobarbituric acid reactive substance (TBARS) and protein carponyl (PC) as well as depletion in the activities of SOD and CAT. Also, a significant increases in concentration of both serum tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) accompanied by decrease in nitric oxide level were observed. Administration of pomegranate extracts, either PJ or PPME significantly mitigated all the signs of AD-induced CRF. The results suggested that the renoprotective efficacy of pomegranate can be attributed to antioxidant, anti-inflammatory and different signaling pathway mechanisms.

Punica granatum, pomegranate, gentamicin, nephrotoxicity

"NEPHROPROTACTIVE EFFECT OF PUNICA GRANATUM EXTRACT IN AN EXPERIMENTAL MODEL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 8, page no.f215-f223, August-2025, Available :http://www.jetir.org/papers/JETIR2508529.pdf

"NEPHROPROTACTIVE EFFECT OF PUNICA GRANATUM EXTRACT IN AN EXPERIMENTAL MODEL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 8, page no. ppf215-f223, August-2025, Available at : http://www.jetir.org/papers/JETIR2508529.pdf