• Sangita Pawar
• Manish Adhyapak
• Devendra Wagare

ABSTRACT: Hemocoagulase drug is widely used as an effective procoagulant during surgical procedures. It prevents excessive blood loss during surgeries by accelerating the hemostasis process. Herbal drugs/medicinal plants have the potential to alter the desired medicinal properties of synthetic and isolated drugs. To study the effect of herbal drugs on the procoagulant activity of hemocoagulase, eighteen medicinal plants were tested to detect potential interference in the functioning of hemocoagulase as a hemostatic agent. Whole blood clotting time of drug-plant ext. was measured, in vitro. Glycyrrhiza glabra and Alium sativium were found to affect the pro-coagulant activity of hemocoagulase. Hence, it is recommended to check the history of consumption of herbal drugs by the patients before doing any major surgery, specifically, tooth extraction surgery, wherein, hemocoagulase is routinely used as a hemostatic drug.

Procoagulant, clotting time, hemocoagulase, drug interactions, hemostasis

"ALTERATION OF PROCOAGULANT ACTIVITY OF HEMOCOAGULASE BY HERBAL DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 8, page no.g443-g447, August-2025, Available :http://www.jetir.org/papers/JETIR2508651.pdf

"ALTERATION OF PROCOAGULANT ACTIVITY OF HEMOCOAGULASE BY HERBAL DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 8, page no. ppg443-g447, August-2025, Available at : http://www.jetir.org/papers/JETIR2508651.pdf