• Dr. Debangshu Agrahari
• Dr. Amit Nampalliwar
• Dr. Mayuri Yawalkar
• Dr. Vinod Kumar

Background: Endometrial hyperplasia (EH) is a gynecological condition marked by abnormal proliferation of the endometrial lining, most commonly due to unopposed estrogen stimulation. It is clinically significant as it causes abnormal uterine bleeding and carries a risk of progression to endometrial carcinoma if left untreated. Current therapeutic options—such as hormonal therapy with progestins, gonadotropin-releasing hormone analogues, and hysterectomy—are effective but often associated with recurrence, adverse effects, or loss of fertility. This necessitates the exploration of safer and more holistic approaches. Ayurvedic Perspective: Ayurveda describes similar pathological states under Artava Dushti and Yonivyapad, wherein vitiation of Kapha, Meda, and Rakta doshas leads to proliferative abnormalities resembling EH. Lekhana Dravyas—agents endowed with “scraping” or “depleting” properties—are specifically indicated in conditions of excessive tissue growth, obesity, metabolic disturbances, Granthi (cysts), and Arbuda (tumorous swellings). Their properties include Laghu (light), Ruksha (dry), Tikshna (sharp), and Ushna (hot), dominated by Katu, Tikta, and Kashaya rasa, which collectively help dissolve and reduce pathological tissue. Objective: This review critically evaluates the role of Lekhana Dravyas in the management of endometrial hyperplasia, correlating classical Ayurvedic descriptions with modern pharmacological evidence. Methods: Classical Ayurvedic texts, authoritative commentaries, and Nighantus were reviewed to identify Lekhana Dravyas and their therapeutic indications. Relevant modern literature was searched using databases such as PubMed, AYUSH Research Portal, and Google Scholar with including “Lekhana Dravyas,” “Ayurveda and endometrial hyperplasia,” and “anti-proliferative herbal drugs.” Pre-clinical and clinical studies on herbs like Guggulu, Triphala, Daruharidra, and formulations like Kanchanara Guggulu were critically analyzed. Results: Evidence suggests that Lekhana Dravyas possess anti-proliferative, anti-inflammatory, antioxidant, hypolipidemic, and hormonal-modulatory activities, which are relevant in preventing and managing endometrial hyperplasia. While classical descriptions emphasize their role in conditions of tissue overgrowth, modern studies have validated specific herbs for their cytotoxic and endocrine-modulating effects. However, most data are preclinical, with limited well-structured clinical trials. Conclusion: Lekhana Dravyas provide a rational and promising Ayurvedic approach to the management of endometrial hyperplasia. They can potentially complement or serve as alternatives to conventional therapy, especially in women seeking fertility-preserving and holistic options. Rigorous clinical research, standardization of formulations, and integrative protocols are essential to establish their role in evidence-based gynecology.

Lekhana Dravyas, guggulu, Pcod, Endometrial Hyperplasia, Hormonal Imbalance.

"A Critical Review of the Role of Lekhana Dravyas in Endometrial Hyperplasia", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 9, page no.d266-d274, September-2025, Available :http://www.jetir.org/papers/JETIR2509340.pdf

"A Critical Review of the Role of Lekhana Dravyas in Endometrial Hyperplasia", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 9, page no. ppd266-d274, September-2025, Available at : http://www.jetir.org/papers/JETIR2509340.pdf