• Dr. Shiv Kumar Rai

Hydantoins are very important organic compounds. They have been synthesised by a fast and general procedure under microwave irradiation. The method is very simple and effective. Syntheses have been achieved only in few minutes instead of 2-3 hours. The denial of use of solvent is a beauty of the work. Under solvent free condition, the yield of the products was found satisfactory. The aim of this work is to minimise the cost of the product in synthesis of different hydantoins of medicinal value under microwave irradiation, even in solvent free condition. Disubstituted-1, 2-diketones 1 (a-c) are heated with urea in the presence of 30% aqueous sodium hydroxide, intermediate heterocyclic pinacols, 2(a-c) are obtained under microwave irradication. Now these intermediate heterocyclic pinacols are cooled diluted with water and on acidification with concentrated hydrochloric acid, give hydantoins 3(a-c) as the result of pinacolic rearrangement. With microwaves at 40% (320W) Level of full power, 8000W of the oven used, the reaction was successfully attempted. The traditional heating 14 requires enough time for completion of reaction about 2 – 3 hours. But it takes only 2-3.5 minutes under microwave irradiation .The purity of the compounds is checked by TLC.

Hydantoins, Microwave irradiation, Solvent free condition,

"Modified Synthesis of Hydantoins under Microwave Irradiation and their Applications", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 9, page no.f593-f596, September-2025, Available :http://www.jetir.org/papers/JETIR2509580.pdf

"Modified Synthesis of Hydantoins under Microwave Irradiation and their Applications", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 9, page no. ppf593-f596, September-2025, Available at : http://www.jetir.org/papers/JETIR2509580.pdf