• Karishma Deepak Kamble
• Pratiksha Rajkumar Ravankole
• Akshada Ransing
• Prashant Rajendra Chandane

Diabetes mellitus is a chronic metabolic disorder affecting millions worldwide. Continuous glucose monitoring (CGM) is essential for effective diabetes management. Traditional methods like finger-prick tests are invasive and often lead to poor patient compliance. In recent years, diabetes patches have emerged as a promising non-invasive alternative for glucose monitoring. The rising prevalence of diabetes mellitus globally underscores the urgent need for improved therapeutic approaches that enhance adherence, minimize side effects, and reduce patient burden. Transdermal patches, particularly those utilizing microneedle arrays and glucose-responsive materials are promising alternatives to traditional insulin injections and oral hypoglycemic agents. This paper reviews recent innovations in diabetes patches, including passive transdermal systems, microneedle-based delivery (solid, coated, and dissolving), and advanced “smart” glucose-responsive patches. It discusses their mechanisms, advantages, limitations, and status in preclinical and clinical development. Real-world trials demonstrate that transdermal insulin delivery methods can match or, in some cases, surpass subcutaneous injections in terms of glycemic control, safety, and patient preference. Challenges such as drug stability, dosing accuracy, cost, and regulatory approval persist. Future directions point to integration with biosensing, closed‐loop systems, and novel materials to bring a new generation of patches into mainstream clinical use. This review explores the evolution, types, mechanisms, advantages, limitations, and future prospects of diabetes patches, highlighting their potential to revolutionize diabetes care. Glucose-responsive drug delivery systems can make it easier for people with diabetes to follow their treatment and keep their blood sugar under control. Although these systems still have some problems, finding ways to solve them will make them easier to use. This review shares new ideas that could help in creating better diabetes medicines in the future.

Transdermal drug delivery, Diabetes patches, Smart insulin delivery, Advanced healthcare materials.

"Advance In Diabetes Patches For Non-Invasive Glucose Monitoring", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 10, page no.a569-a576, October-2025, Available :http://www.jetir.org/papers/JETIR2510072.pdf

"Advance In Diabetes Patches For Non-Invasive Glucose Monitoring", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 10, page no. ppa569-a576, October-2025, Available at : http://www.jetir.org/papers/JETIR2510072.pdf