• Penubolu Sudeep
• Dinesh kumar Govindappa
• Dileep kumar Achutha
• Ajay Kumar Kariyappa

A series of novel pyrazol-1-carboxamide derivatives 5(a-g) was efficiently synthesized through a straightforward cycloaddition reaction between various substituted chalcones and semicarbazide under acidic conditions. The structures of all synthesized compounds were confirmed using spectroscopic techniques like IR, ¹H-NMR, ¹³C-NMR, and mass spectrometry. The antioxidant activity was assessed using multiple in vitro assays, by DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging methods. certain compounds 5C, and 5g shows excellent activity toward radical scavenging activity.

Chalcones, antioxidant activity and DPPH

"Design and Synthesis of Novel pyrazol-1-carboxamide analogues as potent antioxidant agents", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 10, page no.b787-b798, October-2025, Available :http://www.jetir.org/papers/JETIR2510196.pdf

"Design and Synthesis of Novel pyrazol-1-carboxamide analogues as potent antioxidant agents", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 10, page no. ppb787-b798, October-2025, Available at : http://www.jetir.org/papers/JETIR2510196.pdf