• Dr.Aruna B
• K.Sruthi

Cardiac circulatory arrest (CCA), a sudden cessation of effective cardiac output, remains one of the most critical medical emergencies worldwide. Despite advancements in cardiopulmonary resuscitation (CPR) and intensive care, mortality and neurological deficits remain high. Pharmacological therapy plays a pivotal role in optimizing myocardial perfusion, restoring spontaneous circulation, and improving survival outcomes. This review explores the pharmacological strategies used in the management of cardiac circulatory arrest, focusing on catecholamines, vasopressors, antiarrhythmics, adjunctive drugs, and novel experimental agents. Recent advances in molecular pharmacology and targeted therapeutics are discussed, highlighting translational developments that may redefine resuscitation protocols.

Keywords: Cardiac arrest, circulatory arrest, pharmacotherapy, vasopressors, adrenaline, amiodarone, resuscitation drugs, CPR pharmacology

"Therapeutic approaches of cardiac circulatory arrest:A pharmacological perspective ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 10, page no.c148-c158, October-2025, Available :http://www.jetir.org/papers/JETIR2510220.pdf

"Therapeutic approaches of cardiac circulatory arrest:A pharmacological perspective ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 10, page no. ppc148-c158, October-2025, Available at : http://www.jetir.org/papers/JETIR2510220.pdf