• Ms.Neha Deoram Borse
• Mrs.Snehal Dhananjay Jadhav
• Ms.Sakshi M Gaikwad

Human exploration of space for extended missions to the Moon, Mars, and other destinations poses specific challenges for the health of astronauts. Microgravity, cosmic radiation, disrupted circadian rhythms, fluid shift, muscle atrophy, immune alteration, and psychological stress affect health (Kast et al., 2017; Patel et al., 2025). Pharmaceuticals play a critical role in treating conditions in space, such as motion sickness, infection, pain, bone loss, sleep disorders, and cardiovascular problems. Yet, established drug principles might not function equally in space due to modifications of drug absorption, distribution, metabolism, and excretion. In addition, drug stability can be reduced under space environment (Int. J. Pharm, 2025). Experiments on the International Space Station (ISS) have recognized problems such as degradation of drugs by radiation, difficulties with repackaging, and extensive storage periods. Several drugs might be outdated by the time the mission is over (Diaz et al., 2024; Du et al., 2025). Space pharmacology addresses these issues through research on drug stability, formulation, and delivery in microgravity and radiation. It also investigates individualized therapies based on pharmacogenomics (Nelson et al., 2024). New technologies consist of 3D-printed medicines, improved drug delivery systems, AI-driven models, and tele pharmacy to provide efficient medication use in deep-space missions (Varda Space Industries, 2025). Radiation-resistant formulations of drugs, on-demand production of drugs, customized dosing, dispensing systems using automation, and rigorous regulations to harmonize in-flight use of drugs are what future endeavours should prioritize. Blending state-of-the-art monitoring technologies, AI, and pharmacogenomics will enhance the health of astronauts, minimize drug instability, and provide effective treatment. Continued research in space pharmacology is necessary for the continued safe presence of humans in space and the success of missions on interplanetary travel.

Space Pharmacology, microgravity, drug stability, pharmacokinetics in space, pharmacodynamics in space, space medicine, Cosmic Radiation, Long-Duration Space Missions, Astronaut Health, 3D-Printed Pharmaceuticals, Pharmacogenomics, Drug Formulation and Delivery, Space Pharmacy Technologies, In-Flight Medication, Personalized Medicine in Space

"Pharma in space : how medicine work in space mission ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 10, page no.c171-c180, October-2025, Available :http://www.jetir.org/papers/JETIR2510223.pdf

"Pharma in space : how medicine work in space mission ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 10, page no. ppc171-c180, October-2025, Available at : http://www.jetir.org/papers/JETIR2510223.pdf