• Dr. Prerna Saini
• Prof.(Dr.) Suman Lata

In Ayurvedic medicine, Ama symbolizes the earliest disturbance in the body’s internal balance, arising from impaired digestion and metabolism (Agnimandya). It acts as the seed of disease through channel obstruction and Dosha aggravation. Modern biomedical research similarly identifies low-grade metabolic inflammation and endotoxemia as the root of chronic disorders. This article re-examines Ama within the diagnostic discipline of Roga Nidan and correlates it with contemporary concepts such as oxidative stress, gut dysbiosis, and immune dysregulation. By integrating classical descriptions with modern evidence, Ama emerges as a unifying principle that connects digestion, immunity, and mental wellbeing.

Ama, Agni, Roga Nidan, Pathogenesis, Ayurveda, Metabolic Inflammation

"Ama: The Hidden Pathogen of Disease - A Diagnostic Insight", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 10, page no.d780-d783, October-2025, Available :http://www.jetir.org/papers/JETIR2510399.pdf

"Ama: The Hidden Pathogen of Disease - A Diagnostic Insight", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 10, page no. ppd780-d783, October-2025, Available at : http://www.jetir.org/papers/JETIR2510399.pdf