• Ms.Mahajan Mayuri Anil
• Dr. Datir Mahendra Baban
• Ms Bedekar Mansi Raju
• Ms.Chine Vaishnavi Vijay

Oral administration is the preferred route for drug delivery due to its convenience and high patient compliance. Floating tablets offer a promising approach to achieve prolonged and predictable drug release in the gastrointestinal tract, enhancing gastric residence time. This study aimed to develop and evaluate floating pantoprazole tablets, utilizing a gastro-retentive drug delivery system (GRDDS) to improve therapeutic outcomes .Floating drug delivery systems (FDDS) enhance buoyancy, prolonging drug release and reducing dosing frequency. By maintaining intimate contact with the absorbing membrane, GRDDS can maximize drug absorption and modulate its rate. Pantoprazole floating tablets are designed to treat and prevent bacterial infections in the stomach and intestines. Challenges in Oral Controlled Drug Delivery Systems .The primary goal of oral controlled drug delivery systems is to achieve predictable and enhanced bioavailability. However, several physiological challenges exist, including: Limited control over gastric retention: Difficulty in retaining the dosage form in the desired region of the gastrointestinal tract. Variable gastric emptying: Gastric emptying time (normally 2-3 hours) can lead to incomplete drug release, reducing efficacy. These challenges can compromise the effectiveness of oral controlled drug delivery systems.

Pantoprazole, Floating Drug Delivery, Buoyancy, Sustained release

"REVIEW ON FORMULATION AND EVALUATION OF PANTOPRAZOLE FLOATING TABLET", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 11, page no.b201-b205, November-2025, Available :http://www.jetir.org/papers/JETIR2511124.pdf

"REVIEW ON FORMULATION AND EVALUATION OF PANTOPRAZOLE FLOATING TABLET", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 11, page no. ppb201-b205, November-2025, Available at : http://www.jetir.org/papers/JETIR2511124.pdf