Abstract
A well-known medicinal plant with significant pharmacological value is licorice, or Glycyrrhiza glabra L. Glycyrrhizin, glabridin, liquiritigenin, and isoliquiritin are the primary bioactive components that contribute to its wide range of biological activities, including antioxidant, antimicrobial, anti-inflammatory, anticancer, antiviral, hepatoprotective, and antidiabetic effects. It has been demonstrated that glycyrrhizin, a triterpenoid saponin that gives licorice roots their distinctive sweetness, is effective against hepatitis, HIV, and skin conditions. In the food and pharmaceutical industries, it is utilized as a natural sweetener and therapeutic agent. Extracts of Glycyrrhiza glabra have been shown in pharmacological studies to control how the immune system works, stop tumor growth, protect the liver from damage, and stop bacterial and fungal infections. As a natural remedy, its traditional uses include treating respiratory conditions, gastric ulcers, inflammation, and hormonal disorders. Recent advances in extraction and phytochemical enrichment techniques have enhanced the yield of glycyrrhizin and flavonoids, reinforcing Glycyrrhiza glabra’s role as a major candidate in modern pharmacognosy and drug discovery.