Abstract
Piper betle L. (Family: Piperaceae) is an economically and medicinally significant plant widely cultivated in tropical
Asia, particularly India. Traditionally, its leaves are valued for aromatic, stimulant, and therapeutic properties and are
used in Ayurveda, Unani, and Siddha systems of medicine. Phytochemical studies reveal that P. betle leaves contain
diverse bioactive compounds, including phenolics, flavonoids, alkaloids, terpenoids, and essential oils rich in eugenol,
hydroxychavicol, and chavibetol. These compounds are responsible for a broad spectrum of pharmacological
activities, such as antimicrobial, antioxidant, anti-inflammatory, antidiabetic, anticancer, antiulcer, and antihistaminic
effects. Scientific evidence supports its traditional applications in oral hygiene, wound healing, and gastrointestinal
and respiratory health. This review consolidates current literature on the botany, phytochemistry, traditional uses, and
pharmacological properties of Piper betle L., highlighting its therapeutic potential and emphasizing the need for further
pharmacognostic and clinical investigations.