• Anamika D. Vaidya
• Amisha A.Donge
• Dr. Ashish M. Kandalkar
• Dhanshree S. Nibrad
• Dr.Nilesh O. Chachda

Alzheimer's disease (AD) is the main cause of dementia and a major worldwide health concern. Its clinical features include progressive memory loss, cognitive deterioration, and aberrant conduct. Pathologically, AD causes synaptic dysfunction, neuronal degeneration, and brain atrophy through the accumulation of amyloid-β plaques and neurofibrillary tangles composed of hyperphosphorylated tau protein. Current treatments, such as memantine and cholinesterase inhibitors, only slightly reduce symptoms and do not stop the disease's progression. As a result, extensive research is being done to find new treatment approaches that focus on the fundamental causes of AD. Emerging approaches include anti-amyloid and tau-directed therapies, modulation of neuroinflammation, and interventions aimed at restoring mitochondrial function. In parallel, lifestyle modifications such as physical exercise and nutritional optimization are being explored for their potential in prevention and disease delay. Forward-looking innovation involving personalized medicine, gene-editing technologies, and stem cell–based therapies may offer transformative benefits in the future. Continued advancements in AD research are crucial for developing effective disease-modifying treatments and improving patient outcomes.

Keywords: Alzheimer's Disease, Life Style Intervention, Cognitive Impairment, Behavioural Distubance, Cholinesterase Inhibitors.

"ADVANCE IN THE PHARMACOLOGICAL MANAGEMENT OF ALZHEIMER DISEASE CURRENT THERAPIES AND FUTURE PROSPECT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 11, page no.d344-d358, November-2025, Available :http://www.jetir.org/papers/JETIR2511338.pdf

"ADVANCE IN THE PHARMACOLOGICAL MANAGEMENT OF ALZHEIMER DISEASE CURRENT THERAPIES AND FUTURE PROSPECT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 11, page no. ppd344-d358, November-2025, Available at : http://www.jetir.org/papers/JETIR2511338.pdf