• Muskan Dhruvanshi
• Mahima trivedi
• Dr. Ritesh jain

Periodic Paralysis (PP) is a rare group of hereditary muscle disorders marked by recurrent episodes of weakness or temporary paralysis caused by abnormal movement of ions such as potassium, sodium, and calcium across muscle membranes. These ionic disturbances affect muscle excitability and lead to loss of strength. The main types of Periodic Paralysis include Hypokalemic, Hyperkalemic, Andersen–Tawil Syndrome, and Thyrotoxic Periodic Paralysis, each differing in potassium imbalance and clinical features. Dichlorphenamide, a carbonic anhydrase inhibitor, has shown proven effectiveness in both hypokalemic and hyperkalemic forms. It acts by inducing mild metabolic acidosis, stabilizing the muscle membrane potential, and reducing abnormal ion shifts. Clinical studies have demonstrated that Dichlorphenamide lowers the frequency and severity of paralysis attacks, improves muscle function, and enhances patient quality of life. Compared with older therapies such as Acetazolamide and Potassium supplements, Dichlorphenamide provides more consistent control and better tolerability. It is a crystalline, stable, and moderately lipophilic compound suitable for oral dosage forms. Overall, Dichlorphenamide represents an important advancement in the pharmacological management of Periodic Paralysis, offering improved symptom control and long-term therapeutic benefit.

Periodic Paralysis, Dichlorphenamide, Ion Channel Disorders, Carbonic Anhydrase Inhibitor, Hypokalemic Paralysis, Hyperkalemic Paralysis, Muscle Weakness

"Role of dichlorphenamide in management of periodic paralysis - A review ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 11, page no.d804-d812, November-2025, Available :http://www.jetir.org/papers/JETIR2511389.pdf

"Role of dichlorphenamide in management of periodic paralysis - A review ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 11, page no. ppd804-d812, November-2025, Available at : http://www.jetir.org/papers/JETIR2511389.pdf