Abstract
Tephrosia purpurea Linn. (Sarapunkha), a perennial herb widely distributed across India, has long been valued in Ayurvedic and folk medicine for treating liver, spleen, skin, and inflammatory disorders. This review compiles ethnomedicinal knowledge, phytochemical constituents, and pharmacological evidence of the species by analyzing literature from major scientific databases between January 2024 and October 2025. Traditional practices across more than 20 ethnic groups document the use of various plant parts—roots, leaves, seeds, and whole plant preparations—for conditions such as jaundice, hepatosplenomegaly, respiratory complaints, ulcers, wounds, fevers, and infections. Phytochemical studies reveal the presence of flavonoids, rotenoids, triterpenoids, sterols, and tannins, which contribute to its diverse bioactivities. Pharmacological investigations substantiate many of its traditional claims, demonstrating hepatoprotective, antioxidant, anti-inflammatory, antimicrobial, antidiabetic, nephroprotective, and wound-healing effects in experimental models. The integration of traditional knowledge with modern scientific validation highlights Tephrosia purpurea as a therapeutically significant medicinal plant and a promising source for future drug development.