• SALEEL T
• MAHALAKSHMI S

This article provides a comprehensive overview of self-nanoemulsifying drug delivery systems (SNEDDS), Drugs which are poorly water solubility are made well suitable for lipid-based formulation. Water insoluble and weakly basic drugs require special care in the design and development of lipid based formulation. A majority of novel pharmacologically active constituents produced in recent drug discovery programs are lipophilic and poorly soluble, posing a significant problem for enhancing the oral bioavailability of such drug molecules.A novel method designed to enhance the bioavailability of poorly water-soluble drugs. It highlights the formulation components, including oils, surfactants, and co-surfactants, which facilitate the formation of nano emulsions upon contact with aqueous media. In the human body, the agitation required for formation of nano emulsions is provided by digestive motility of the gastrointestinal tract.The article discusses various characterization techniques employed to evaluate the physicochemical properties of SNEDDS, including droplet size, zeta potential, and stability studies. Further more,advantages of using SNEDDS, such as improved solubility, targeted delivery, and enhanced therapeutic efficacy also disadvantages. Challenges in formulation and applications are addressed.

Self nano emulsifying drug delivery system, Bezafibrate, Poorly water soluble drugs , Surfactant and Co surfactant, 0ral bio-availability, Solubility.

"AN OVERVIEW ON SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 11, page no.e223-e234, November-2025, Available :http://www.jetir.org/papers/JETIR2511428.pdf

"AN OVERVIEW ON SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 11, page no. ppe223-e234, November-2025, Available at : http://www.jetir.org/papers/JETIR2511428.pdf