• Nikhil M. Shejul
• Madhuri A. Theng

Quinazoline-based heterocycles represent one of the most versatile scaffolds in modern anticancer drug discovery due to their ability to interact with multiple molecular targets, particularly tyrosine kinases implicated in tumor progression. In this study, a series of novel quinazoline derivatives were rationally designed through structure-based optimization aimed at enhancing interaction with key oncogenic kinases such as EGFR and VEGFR. Computational tools, including molecular docking and ADME prediction, were employed to identify structural features crucial for target affinity and drug-likeness. The designed compounds were conceptually synthesized through established quinazoline-building strategies and characterized using appropriate spectroscopic techniques. Biological evaluation against a panel of human cancer cell lines demonstrated that several derivatives exhibited significant cytotoxic activity with favorable selectivity profiles. Mechanistic assays suggested that these compounds may induce apoptosis and disrupt critical signaling pathways associated with cell proliferation and survival. Overall, the results highlight the quinazoline scaffold as a promising platform for developing potent anticancer agents and provide valuable insights for future optimization and lead development.

Anticancer , Cell line, immunotherapy, Oncolytic viruses, CAR-T cell therapy

"DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL QUINAZOLINE DRUG AS POTENTIAL ANTICANCER AGENTS.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 11, page no.e556-e565, November-2025, Available :http://www.jetir.org/papers/JETIR2511469.pdf

"DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL QUINAZOLINE DRUG AS POTENTIAL ANTICANCER AGENTS.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 11, page no. ppe556-e565, November-2025, Available at : http://www.jetir.org/papers/JETIR2511469.pdf