• Samruddhi S. Khonde
• Rashmi R. Lokhande
• Rohini V. Bhojane
• Rasika S. Shelke
• Priti D. Barange

Oral thin films (OTFs) have emerged as a cutting-edge drug delivery platform designed for enhanced patient-centric care. These thin, rapidly dissolving films provide a convenient alternative to traditional oral dosage forms, enabling fast drug release and absorption through the oral mucosa, which bypasses first-pass metabolism and improves bioavailability. OTFs are particularly beneficial for pediatric, geriatric, and dysphagic patients who face difficulties swallowing tablets or capsules. Advances in manufacturing techniques, such as solvent casting, hot melt extrusion, and novel printing technologies including inkjet and 3D printing, have enabled precise dosing, personalized therapies, and rapid onset of action. The films can also incorporate taste masking and controlled release features, further improving patient compliance and therapeutic efficacy. On the regulatory front, global agencies are evolving guidelines to ensure safe, effective OTF quality control and manufacturing standards, fostering wider adoption. The OTF market is rapidly growing, reflecting the increasing demand for user-friendly, efficient drug delivery systems. Future directions explore multilayer films and multi-drug combinations, positioning OTFs as transformative solutions in modern pharmacotherapy and nutraceutical applications. This review elucidates these advances and regulatory perspectives underpinning the OTF landscape today and beyond.

Patients-Centric Drug Delivery,Fast-Dissolving Films, Oral thin films (OTF), Regulatory Guidelines

"Advances in Oral Thin Films: Modern Strategies for Patient-Centric Drug Delivery and Global Regulatory Perspectives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 11, page no.e862-e879, November-2025, Available :http://www.jetir.org/papers/JETIR2511508.pdf

"Advances in Oral Thin Films: Modern Strategies for Patient-Centric Drug Delivery and Global Regulatory Perspectives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 11, page no. ppe862-e879, November-2025, Available at : http://www.jetir.org/papers/JETIR2511508.pdf