• Atul Kumar
• Iffat Hussain
• Aftab khan
• Amit Kumar Ahirwar

Pharmaceutical creams are semisolid topical formulations designed to deliver therapeutic agents through the skin for the treatment of local or systemic conditions. Structurally, they are emulsions of either the oil-in-water (O/W) or water-in-oil (W/O) type, composed of an oil phase, aqueous phase, and suitable emulsifiers. The formulation of effective creams requires careful selection of active ingredients and excipients such as oils, waxes, humectants, surfactants, and stabilizers to ensure optimal stability, efficacy, and patient acceptability. Various types of creams including vanishing, cold, foundation, night, and protective creams are prepared to meet cosmetic and therapeutic requirements. Drug selection depends on physicochemical properties such as solubility, partition coefficient, molecular weight, and stability. The manufacturing process involves controlled heating, emulsification, and cooling to produce a stable product. Evaluation parameters like pH, viscosity, spreadability, saponification value, acid value, stability, and irritancy are used to assess the quality and performance of the formulation. Overall, topical cream formulation represents a balanced integration of pharmaceutical science and cosmetic technology aimed at ensuring safety, stability, and therapeutic effectiveness.

Cream

"CREAMS AS TOPICAL DRUG DELIVERY SYSTEM: A DETAILED REVIEW ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 12, page no.a720-a733, December-2025, Available :http://www.jetir.org/papers/JETIR2512096.pdf

"CREAMS AS TOPICAL DRUG DELIVERY SYSTEM: A DETAILED REVIEW ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 12, page no. ppa720-a733, December-2025, Available at : http://www.jetir.org/papers/JETIR2512096.pdf