• Sayali Dnyaneshwar Gadekar
• Dr. Datir Mahendra Baban
• Sonal Surendra Magar

Irbesartan is an angiotensin II receptor blocker (ARB) commonly used for the treatment of hypertension. Its effectiveness mainly depends on two important factors — it belongs to the Biopharmaceutics Classification System (BCS) Class II category, meaning it has low solubility but high permeability, and it has a narrow absorption window in the upper part of the gastrointestinal (GI) tract. Because its biological half-life ranges between 11 and 15 hours, a sustained release formulation is needed to maintain 24-hour therapeutic action. Conventional tablets often move rapidly through the GI tract, which can lead to incomplete absorption and fluctuating plasma levels. To overcome this issue, gastroretentive drug delivery systems (GRDDS), particularly floating tablets, have been developed. These systems help the tablet remain in the stomach for a longer time, allowing a controlled and continuous release of the drug at its main absorption site. The review also discusses gastric physiology, such as the migrating motor complex, and explains the principles of flotation, both effervescent and non-effervescent. The importance of polymers like HPMC and Carbopol, along with solubility-enhancing techniques such as solid dispersions and cyclodextrin complexes, is also highlighted. Finally, it covers different characterization methods, including in vitro release kinetics and in vivo evaluation using gamma scintigraphy.

Irbesartan, Biopharmaceutics Classification, Gastroretentive Drug Delivery Systems, floating tablets

"A COMPREHENSIVE REVIEW ON THE IRBESARTAN GASTRORETENTIVE FLOATING TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 12, page no.b70-b73, December-2025, Available :http://www.jetir.org/papers/JETIR2512111.pdf

"A COMPREHENSIVE REVIEW ON THE IRBESARTAN GASTRORETENTIVE FLOATING TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 12, page no. ppb70-b73, December-2025, Available at : http://www.jetir.org/papers/JETIR2512111.pdf