• Khawle Balaji Mukundrao
• Dr.Padmaja Sidram Giram
• Ajgunde B.R

Breast cancer remains a formidable global health challenge, necessitating the development of novel, effective, and less toxic therapeutic agents to overcome the limitations of conventional treatments, such as systemic toxicity and drug resistance. Nanotechnology, particularly the green synthesis of silver nanoparticles (AgNPs): offers a promising, eco-friendly solution by leveraging the bioactive potential of medicinal plants. This review systematically covers the integration of the medicinal plant Bryophyllum pinnatum (B. pinnatum): renowned for its rich phytochemical profile (including flavonoids, triterpenoids, and phenols) and documented anticancer properties with nanotechnology to create advanced breast cancer nanomedicine. We review the green synthesis approach, which utilizes the plant's phytochemicals as both reducing and stabilizing agents to produce biocompatible AgNPs. Furthermore, we synthesize the evidence demonstrating the multifunctional biological activities of these biogenic nanoparticles, including potent in vitro cytotoxicity against the human breast cancer cell line MCF-7 via mechanisms like apoptosis induction and cell cycle arrest. Importantly, the review also highlights the significant antioxidant, anti-inflammatory, and antibacterial properties of the AgNPs, positioning them as comprehensive therapeutic agents capable of reducing oxidative stress and combating secondary infections in immunocompromised cancer patients. This review validates B. pinnatum-mediated AgNPs as a sustainable, cost-effective, and highly promising next-generation therapeutic strategy for breast cancer management.

Breast Cancer, Green-Synthesized Silver Nanoparticles (AgNPs), Bryophyllum pinnatum, Nanotherapeutics, MCF-7 Cytotoxicity Mechanism, Apoptosis and Cell Cycle Arrest Induction, Reactive Oxygen Species (ROS), Eco-Friendly Nanoparticle Synthesis, Biocompatible Plant-Derived Nanocarriers

"Invitro pharmacological evaluation of Bryophallum pinnatum in breast cancer therapy by silver nanoparticles", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 12, page no.b275-b283, December-2025, Available :http://www.jetir.org/papers/JETIR2512142.pdf

"Invitro pharmacological evaluation of Bryophallum pinnatum in breast cancer therapy by silver nanoparticles", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 12, page no. ppb275-b283, December-2025, Available at : http://www.jetir.org/papers/JETIR2512142.pdf