• Vaishnavi Kiran Chivte
• Mr.Ogar Bhalaram Choudhary
• Dr. Vijaykumar Kale
• Dr. Mahesh Thakare
• Mr. Vaibhav Narwade

Granulation is a vital processing step in pharmaceutical manufacturing that converts loose, fine powders into larger, mechanically stronger, and more flowable granules. This transformation improves powder handling, ensures uniformity of drug content, enhances compressibility, and supports the production of high-quality tablets. Among the various methods available, wet granulation and dry granulation are the two most widely used techniques, each offering specific benefits based on the characteristics of the drug and excipients involved. Wet granulation relies on the incorporation of a liquid binding medium to promote particle adhesion and controlled agglomerate growth, making it suitable for formulations requiring robust granule strength and superior content uniformity. In contrast, dry granulation employs mechanical pressure either by roller compaction or slugging to consolidate powders without the use of moisture, making it ideal for heat-sensitive or moisture-sensitive active pharmaceutical ingredients (APIs). This project presents a comprehensive comparison of wet and dry granulation methods, discussing their operating principles, process parameters, advantages, limitations, and industrial relevance. The review also highlights key research contributions, current manufacturing challenges, and emerging innovations such as continuous granulation, automation, and AI-assisted process control. Together, these insights underline the essential role of granulation in ensuring consistent product quality and in advancing modern pharmaceutical manufacturing practices.

Wet Granulation, Dry Granulation, Roller Compaction, Particle Agglomeration, Flowability

"A CRITICAL REVIEW ON WET AND DRY GRANULATION IN PHARMACEUTICALS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 12, page no.c94-c103, December-2025, Available :http://www.jetir.org/papers/JETIR2512210.pdf

"A CRITICAL REVIEW ON WET AND DRY GRANULATION IN PHARMACEUTICALS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 12, page no. ppc94-c103, December-2025, Available at : http://www.jetir.org/papers/JETIR2512210.pdf